Semax Differentially Modulates GABA and Glycine Currents in Rat Brain Neurons

Semax, a synthetic peptide derived from a fragment of adrenocorticotropic hormone (ACTH), is widely recognized for its diverse nootropic (cognitive-enhancing) and neuroprotective properties. It has been explored for its potential in improving memory, attention, and recovery from various neurological injuries. Despite its established beneficial effects on overall brain function and cognitive performance, the precise molecular and cellular mechanisms by which Semax exerts these actions, particularly its direct interactions with fundamental inhibitory neurotransmitter systems such as GABA (gamma-aminobutyric acid) and glycine, have remained incompletely elucidated at the level of individual neuronal activity. This study was specifically designed to bridge this knowledge gap by investigating how Semax directly modulates the ionic currents activated by these crucial inhibitory neurotransmitters in isolated brain neurons, providing a clearer picture of its immediate impact on neuronal excitability.