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selank anxiolytic other n=60 2026-04-03 PubMed

Selank Peptide Shows Lasting Anxiety Relief Compared to Phenazepam

[A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders].

Background

Anxiety disorders, including phobic-anxiety- and somatoform disorders, affect millions globally, significantly impacting quality of life. Current treatments often involve benzodiazepines like Phenazepam, which can have side effects and dependency issues. There is a critical need for novel anxiolytics with improved safety profiles and sustained efficacy. This study specifically aimed to evaluate the anxiolytic effect and tolerability of the peptide Selank in comparison to Phenazepam.

Results

The study demonstrated a pronounced anxiolytic effect for Selank, alongside a mild nootropic effect (improving cognitive functions like memory and focus). Crucially, Selank's anxiolytic effect was observed to persist for a full week after the last administration of the peptide, indicating a sustained benefit. In addition to its primary anxiolytic action, Selank also had a positive impact on the overall quality of life of the patients. The abstract highlights Selank's unique benefits and tolerability, implying a favorable comparison to Phenazepam without providing specific quantitative differences in efficacy or side effects. The most important finding is the sustained anxiolytic effect of Selank, lasting for a week post-treatment, which is a significant advantage over many short-acting anxiolytics.

Why It Matters

This research significantly extends therapeutic possibilities for managing anxiety disorders by introducing Selank as a potentially superior alternative to traditional anxiolytics. The peptide's prolonged anxiolytic effect could lead to improved patient adherence and a reduced burden of daily medication, offering a substantial advantage over compounds requiring frequent dosing. These findings underscore Selank's potential to be developed into a new clinical treatment option for anxiety disorders. Future research should focus on larger Phase II/III human trials to establish optimal dosing, long-term efficacy, and a comprehensive safety profile.


selank anxiolytic nootropic safety data present
Source: pubmed:25176261 · Ingested 2026-04-03 · Digest: gemini-2.5-flash