Retatrutide's Impact on Metoprolol Absorption Explored in Healthy Individuals
To Investigate the Effect of Retatrutide (LY3437943) on Metoprolol Pharmacokinetics in Healthy Participants
Background
Retatrutide is a novel triple agonist targeting GLP-1, GIP, and glucagon receptors, currently under investigation for obesity and type 2 diabetes. Metoprolol is a widely used beta-blocker prescribed for conditions like hypertension and angina. Given that Retatrutide can affect gastric emptying, there's a potential for it to alter the absorption and overall pharmacokinetics (PK) of co-administered oral medications. This study specifically aimed to determine if Retatrutide significantly impacts the systemic exposure of Metoprolol in healthy participants.