105 studies on GHRP-6 curated from PubMed, ClinicalTrials.gov, and EuropePMC. Updated daily.
This research provides a mechanistic understanding of how enteral nutrition combats hypercatabolism, highlighting the critical role of the ghrelin/GHS-R1α-POMC pathway. The findings suggest that optimizing enteral fee…
This research highlights Meranzin Hydrate's potential as a novel therapeutic agent for depression and associated motor deficits, acting through the ghrelin system and neuroplasticity pathways. The findings suggest a p…
This research uncovers a novel mechanism by which oral L-ornithine stimulates growth hormone (GH) secretion, specifically implicating ghrelin receptor-mediated pathways. Understanding this interaction could open new a…
This study provides compelling evidence that targeting ghrelin receptors in the brain offers a novel therapeutic strategy for NAFLD and associated metabolic dysfunctions. By improving hypothalamic insulin resistance, …
This research provides compelling evidence that ghrelin acts as a potent pro-angiogenic factor, directly stimulating new blood vessel formation in human heart cells under oxygen-deprived conditions. This finding is hi…
This study provides critical insights into the metabolic regulatory functions of ghrelin, particularly its role in modulating liver fat and glucose metabolism. The findings suggest that ghrelin's normal activity might…
This groundbreaking study offers vital new insights into the complex neurobiological underpinnings of nicotine addiction, highlighting the previously underappreciated role of ghrelin, a peptide hormone known for its i…
This research highlights the critical importance of ghrelin balance for successful embryo implantation and pregnancy outcomes, extending its known roles beyond metabolism. Understanding how ghrelin misbalance disrupts…
This research highlights ghrelin's potential as a therapeutic agent for managing GDM by targeting the underlying mechanism of ER stress. By mitigating ER stress in placental cells and improving glucose metabolism, ghr…
This study highlights Ghrelin's significant potential as a therapeutic agent for preventing or treating intestinal ischemia-reperfusion injury. By modulating the GHSR-1α/Sirt1/FOXO1 pathway, Ghrelin offers a novel and…
This research highlights GHRP-6 as a promising therapeutic agent to protect against the severe organ damage caused by doxorubicin chemotherapy. By activating intrinsic prosurvival mechanisms, GHRP-6 could potentially …
This research highlights ghrelin as a potential therapeutic agent for combating pancreatic β-cell dysfunction and apoptosis, which are central to the progression of type 2 diabetes. By targeting ER stress and the IRE1…
This groundbreaking research provides a fundamental and unprecedented understanding of how ghrelin directly influences cellular excitability and signaling by precisely modulating VGCCs. This direct molecular interacti…
The study yielded compelling evidence that ghrelin is indeed indispensable for the characteristic blood pressure reduction during torpor. A striking difference was observed: ghrelin-deficient mice exhibited a signific…
This study provides compelling evidence that intranasal delivery is a viable and effective route for engaging the brain's ghrelin signaling system. This non-invasive approach could circumvent the challenges of systemi…
This study highlights a novel therapeutic target for managing the challenging symptoms of nicotine withdrawal. By demonstrating that Ghrelin and GHRP-6 can significantly reduce withdrawal-induced hyperactivity, these …
This study provides crucial preclinical safety data, strongly supporting the continued development of CIGB-500 as a potential therapeutic agent. The robust safety profile observed in beagle dogs at high doses, includi…
This study provides compelling evidence for ghrelin's ability to promote significant neurological recovery and neurogenesis in the chronic phase after stroke. Its capacity to stimulate new neuron formation and improve…
This research highlights Danshen-Chuanxiong-Honghua (DCH) as a promising multi-target therapeutic agent for traumatic brain injury, offering both anti-inflammatory and neuroprotective benefits. The specific identifica…
This research highlights the significant potential of GHRP-6 as a functional feed additive in aquaculture, offering a novel strategy to enhance both growth performance and disease resistance in farmed fish. The abilit…
This research provides compelling evidence for the potential of GHRP-6 as a novel therapeutic agent to enhance human oocyte quality and maturation, which could significantly improve success rates for infertility treat…
This study introduces aza-Isotryptophan as a novel and versatile building block for peptide chemistry, significantly expanding the chemical space available for designing new peptide-based drugs. The ability of azaItr-…
This groundbreaking study provides compelling evidence that the GHRP-6 hydrogel represents a highly promising and innovative therapeutic strategy for Acute Kidney Injury. Its unique ability to provide sustained local …
This research establishes a critical direct neuroendocrine link between the ghrelin signaling pathway and the regulation of AVP, a key component of the body's stress response system and fluid homeostasis. Understandin…
This research highlights a novel regulatory mechanism for ACTH secretion, involving the interplay between BMP and GHRP signaling pathways. Understanding these interactions is crucial for comprehending the intricate co…
Improved and more sensitive detection methods are paramount for maintaining the integrity and fairness of competitive sports. By identifying novel metabolites and optimizing analytical protocols, this research signifi…
The discovery of ghrelin fundamentally transformed our understanding of growth hormone regulation, appetite control, and energy balance. It revealed a novel endocrine system linking the gut directly to the brain's neu…
This research provides crucial analytical standards and degradation profiles that can significantly enhance anti-doping detection capabilities. By understanding how these peptides break down, forensic laboratories can…
This research provides compelling evidence that human pituitary adenomas express functional growth hormone secretagogue receptors, which can directly influence hormone secretion. This discovery is crucial because it s…
This study provides crucial insights into the neurobiological mechanisms underlying chronic GHS action, particularly their influence on hypothalamic circuits regulating energy balance. The observed upregulation of ore…
This landmark review fundamentally reshaped the understanding of GH modulation, establishing GHSs as a powerful and physiologically relevant therapeutic strategy. By stimulating endogenous GH, GHSs offered a pathway t…
The study successfully identified adenosine as a partial agonist of the GHS-R, meaning it can activate the receptor but not to its full potential. Activation of GHS-R by adenosine was significantly inhibited by select…
This groundbreaking research significantly expands our understanding of GHS physiology, indicating that these compounds, and potentially the endogenous ligand ghrelin, have direct actions on multiple peripheral organs…
This foundational review consolidated critical knowledge about the GHS-R system, providing a robust framework that significantly influenced subsequent research and drug discovery efforts. It highlighted the immense po…
This research highlights a novel and potentially significant role for synthetic peptidyl GH secretagogues beyond their traditional endocrine functions, suggesting they could be repurposed as direct anticancer agents. …
This research is crucial as it highlights the potential of ghrelin and synthetic growth hormone secretagogues as novel therapeutic agents for treating acute ischemic heart disease, such as myocardial infarction (heart…
The development of GHSs represents a paradigm shift in treating conditions associated with GH deficiency or catabolic states. These compounds offer a non-invasive, orally active alternative to recombinant GH, potentia…
This study marks a significant advancement by identifying Ipamorelin as the first truly selective growth hormone secretagogue, offering a cleaner pharmacological profile. The absence of significant prolactin or cortis…
This foundational research is profoundly significant as it underscores the promising potential of GH secretagogues as a novel therapeutic strategy for managing and preventing conditions characterized by bone loss, suc…
This study reveals a critical GH-independent mechanism by which GHSs can increase body fat, potentially driven by increased feeding and altered metabolic signaling. This finding is highly significant for understanding…
This research provides a crucial mechanistic insight into how GHRPs stimulate growth hormone release, suggesting a significant interaction with the body's endogenous ghrelin system. Understanding this pathway could le…
This study highlights a critical paradox in diabetes: GH hypersecretion coexisting with peripheral GH receptor resistance. This finding suggests that the body attempts to compensate for impaired GH signaling by increa…
This study provides a highly sensitive and robust analytical tool that significantly enhances the capabilities of anti-doping laboratories to detect GHRP abuse. By simultaneously identifying both parent GHRPs and thei…
This advanced analytical method provides a crucial tool for anti-doping agencies to combat the illicit use of GHRPs in both equine and human sports. By enabling reliable and high-throughput detection, it helps ensure …
This research significantly enhances anti-doping capabilities by providing specific, long-lasting biomarkers for GHRPs administered nasally. The identification of these metabolites means that athletes misusing these s…