Macimorelin oral stimulation investigated as novel copeptin diagnostic in healthy volunteers

Polyuria-polydipsia syndrome presents a diagnostic challenge, often requiring complex and invasive tests to differentiate between various underlying causes of excessive thirst and urination. Current diagnostic approaches, such as water deprivation tests, can be time-consuming and carry risks. Copeptin, a stable surrogate marker for arginine vasopressin (AVP), is crucial for diagnosing disorders of water balance. A less invasive, more convenient method for stimulating AVP release, and thus copeptin, is needed to improve diagnostic accuracy and patient experience for these conditions.