GLP-1 Agonists: Do They Reduce Anxiety? A Comprehensive Systematic Review

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a class of medications primarily recognized for their efficacy in managing type 2 diabetes and promoting weight loss in individuals with obesity. Beyond their well-established metabolic benefits, there is growing interest and accumulating preclinical evidence suggesting that these compounds may exert significant effects on the central nervous system, potentially influencing mood and anxiety-related behaviors. However, a definitive and comprehensive understanding of the precise impact of GLP-1 receptor agonists on anxiety levels across diverse patient populations and various study designs has remained elusive, necessitating a rigorous synthesis of the existing scientific literature.