Unpacking TB-500's Chemical Blueprint: A PubChem Profile Deep Dive

TB-500 is a synthetic peptide, a truncated version of the naturally occurring thymosin beta-4 protein. Thymosin beta-4 plays a crucial role in various biological processes, including cell migration, angiogenesis (the formation of new blood vessels), and tissue regeneration, making its synthetic derivatives like TB-500 of significant interest in regenerative medicine research. Before any biological activity can be explored, a precise and universally recognized chemical identification is paramount to ensure consistency and reproducibility across scientific investigations.

The PubChem profile assigns TB-500 a unique Compound ID (CID) of 62707662, a critical identifier for database cross-referencing. Its molecular formula is precisely C38H68N10O14, indicating the exact count of carbon, hydrogen, nitrogen, and oxygen atoms within the peptide structure. This formula confirms its composition as a relatively small peptide. The molecular weight is accurately determined as 889.0 g/mol, a fundamental physical property essential for laboratory calculations and characterization. The detailed IUPAC name, (2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-4-methylpentanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-3-hydroxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]-5-amino-5-oxopentanoic acid, provides an unambiguous, systematic description of its amino acid sequence and modifications, ensuring its exact chemical structure is known.