Targeting Growth Hormone-Releasing Hormone Receptor Induces Specific Cell Death in Retinoblastoma
Antagonists of growth hormone-releasing hormone receptor induce apoptosis specifically in retinoblastoma cells.
Background
Retinoblastoma is an aggressive childhood eye cancer, often leading to vision loss or enucleation (surgical removal of the eye). Current treatments, including chemotherapy and radiation, are effective but carry significant risks, such as secondary cancers, vision impairment, and developmental issues in pediatric patients. There is a critical need for more targeted and less toxic therapies. This study addresses the knowledge gap regarding the role of growth hormone-releasing hormone (GHRH) receptor signaling in retinoblastoma progression and its potential as a novel therapeutic target.