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semaglutide glp 1 agonist other 2019-04-30 ClinicalTrials

Semaglutide Explored for Direct Impact on Heart Artery Plaque in Type 2 Diabetes

Semaglutide Treatment On Coronary Progression

Background

Patients living with Type 2 Diabetes face a significantly heightened risk of developing Coronary Artery Disease (CAD), a severe condition driven by atherosclerosis—the progressive accumulation of fatty plaques within the arteries supplying the heart. This plaque buildup can lead to blockages, heart attacks, and strokes. While Semaglutide, a GLP-1 receptor agonist, has demonstrated remarkable efficacy in improving glycemic control and facilitating weight loss, a crucial scientific question remains: does Semaglutide directly influence, slow, or even reverse the progression of existing coronary atherosclerotic plaque?

Study Design

Population
Patients with Type 2 Diabetes and Coronary Artery Disease (CAD) driven by atherosclerosis.
Intervention
Semaglutide, a GLP-1 receptor agonist; dose, route, and duration not specified.
Outcome
Direct influence, slowing, or reversal of existing coronary atherosclerotic plaque progression.

semaglutide glp 1 agonist glp-1r dose mentioned protocol relevant
Source: clinicaltrials:NCT03985384 · Ingested 2026-04-30 · Digest: gemini-2.5-flash