Comprehensive Clinical Trial to Improve Mid-Life Women's Health During Menopause Transition

The menopausal transition is a critical period where mid-life women experience significant physiological changes, inherently increasing their risk for future cardiometabolic disease due to factors like declining estrogen and shifts in metabolic function. This phase is also characterized by heightened inflammation, accelerated epigenetic aging (changes in gene expression patterns that reflect biological age), and often debilitating menopausal symptoms like hot flashes. Despite these well-documented challenges, there remains a notable gap in comprehensive, evidence-based strategies, meaning there isn't a single, integrated suite of interventions designed to holistically address these multifaceted health challenges during menopause.