Probiotic PS150 Investigated for Improving Sleep and Mental Health

Insomnia is a widespread sleep disorder affecting millions, often leading to impaired daily functioning and increased risk of other health issues like anxiety and depression. Emerging research suggests a strong connection between gut microbiome health and brain function, known as the gut-brain axis, which could influence sleep patterns. This clinical trial aims to evaluate if the specific probiotic strain PS150 can effectively reduce insomnia symptoms and improve sleep quality.

This study is currently in its registration phase, so no results are available yet; however, it aims to determine if PS150 can significantly reduce insomnia symptoms and improve overall sleep quality compared to placebo. Researchers will assess changes in sleep indices, autonomic nervous system functioning, and the severity of anxiety and depressive symptoms. The trial also seeks to establish if PS150 can modulate the gut microbiome and endocrine functions, providing a mechanistic understanding of its potential effects. The primary objective is to demonstrate a statistically significant improvement in sleep parameters and a reduction in insomnia severity in the PS150 group after 30 days of intervention. Furthermore, the trial will investigate PS150's potential to adjust gut microbiome composition and endocrine functions, seeking to establish a mechanistic link between probiotic intervention and improved sleep.