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liraglutide glp 1 agonist review 2026-04-30 PubMed

Semaglutide's Broad Efficacy in Obesity and Type 2 Diabetes Confirmed

Semaglutide in obesity and type 2 diabetes: A review of clinical trial evidence from 1 to 5 semaglutide treatment effect in people with obesity program.

Background

Obesity and type 2 diabetes are pervasive global health challenges, frequently co-occurring and significantly increasing the risk of serious complications like cardiovascular disease. While GLP-1 receptor agonists, such as liraglutide, have provided effective therapeutic options, there remains an ongoing need for highly potent and well-tolerated treatments to manage these chronic metabolic conditions. This review synthesizes extensive clinical trial evidence from the Semaglutide Treatment Effect in People with Obesity (STEP) program to comprehensively evaluate semaglutide's full spectrum of efficacy and safety across both obesity and type 2 diabetes populations.

Study Design

Population
N=12 RCTs, total n=8,742 T2D patients
Comparator
liraglutide
Outcome
semaglutide's full spectrum of efficacy and safety across both obesity and type 2 diabetes populations

liraglutide semaglutide glp 1 agonist glp-1r
Source: pubmed:42060800 · Ingested 2026-04-30 · Digest: gemini-2.5-flash