Targeting Cellular Senescence to Improve Kidney Transplant Outcomes
Cellular senescence as a therapeutic target to improve renal transplantation outcome.
Background
Renal transplantation is a life-saving procedure for end-stage renal disease, but long-term success is often limited by graft dysfunction and chronic allograft nephropathy. These complications are driven by various factors, including inflammation and fibrosis, which progressively damage the transplanted kidney. Despite advancements in immunosuppression, a significant knowledge gap remains regarding the precise role of cellular senescence in these processes and its potential as a therapeutic target.
Study Design
Population
Patients undergoing renal transplantation for end-stage renal disease, experiencing graft dysfunction and chronic allograft nephropathy.
Intervention
FOX04-DRI peptide, dose, route, and duration not specified.
Outcome
The study aims to investigate the precise role of cellular senescence in graft dysfunction and chronic allograft nephropathy and its potential as a therapeutic target.