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cagrilintide amylin agonist rct 2025-02-10 ClinicalTrials

New Phase 3 Trial Investigates Long-Term CagriSema for Obesity Weight Loss

A Research Study to Look Into the Long-term Effect on Weight Loss of CagriSema in People With Obesity

Background

The fixed-dose combination of semaglutide (a GLP-1 receptor agonist) and cagrilintide (an amylin analog), known as CagriSema, has already demonstrated significant and clinically relevant body weight reductions in adults with overweight or obesity in previous trials. However, the long-term efficacy and safety of this powerful combination over an extended period remained to be fully established.

Study Design

Population
Adults with overweight or obesity.
Intervention
CagriSema (fixed-dose combination of semaglutide and cagrilintide).
Outcome
Long-term efficacy and safety, specifically body weight reductions.

cagrilintide semaglutide amylin agonist glp 1 agonist glp-1r dose mentioned protocol relevant
Source: clinicaltrials:NCT06780449 · Ingested 2026-05-05 · Digest: gemini-2.5-flash